What is porb?
Porb is a word that has many meanings. It can refer to sexually explicit material, such as pictures or writing, that is designed to cause arousal. It can also refer to the presentation or production of this material. It can also refer to a pirn, which is a rod that thread is wrapped around for weaving.
The exact molecular mechanisms by which PorB facilitates antigen uptake and transport into endosomes are not yet fully understood, although it is likely to be clathrin and caveolin dependent. However, it has been shown that PorB enhances immune responses in vivo, including IFN
It is also possible that PorB acts as an adjuvant during vaccination, increasing the effectiveness of a vaccine. This is supported by the observation that PorB is able to increase protection in a mouse model of pulmonary TB when administered in conjunction with Pam3CSK4. This suggests that PorB may help to facilitate antigen processing and MHC class II presentation.